CJC-1295 DAC – 5MG

Scientific Overview of CJC-1295 DAC

CJC-1295 DAC is a synthetic peptide modeled after growth hormone-releasing hormone (GHRH). It incorporates a drug affinity complex (DAC), which is thought to extend its presence in circulation by associating with plasma proteins. Structural variations within the first 29 amino acids of GHRH have been introduced to increase stability against enzymatic breakdown. The DAC component is linked to the peptide through a lysine derivative, which may help prolong the duration of its activity.

Alternative Names: CJC-1295 with DAC

CJC-1295 DAC Studies and Research Data

Research on Growth Hormone Release

Initial studies with murine models suggest that CJC-1295 DAC may stimulate growth hormone production, sometimes up to several times above baseline levels. These increases appeared shortly after introduction and, in some reports, were sustained for days. Investigations propose that this peptide may support natural cyclical hormone release patterns rather than forcing a constant elevation. Further studies also suggest potential downstream signaling through the JAK-STAT pathway, which could influence the transcription of IGF-I.

CJC-1295 DAC Studies on Pituitary Receptor Interactions

CJC-1295 DAC has been observed to interact with growth hormone-releasing hormone (GHRH) receptors in pituitary cells. This interaction may activate G-protein signaling pathways, leading to the generation of secondary messengers such as cAMP and IP3. These molecules may, in turn, activate protein kinases that regulate transcriptional activity inside somatotroph cells, possibly influencing growth hormone gene expression.

Research in Growth Patterns and Composition

Findings in murine models with disrupted growth hormone function suggest that CJC-1295 DAC may contribute to stabilizing growth hormone release and supporting lean mass retention. Some evidence points to possible influences on body composition, including changes in lean and fat mass balance. Increased pituitary RNA and GH mRNA have also been reported, indicating that the compound may stimulate somatotroph cell populations.

CJC-1295 DAC Investigations in Reproductive Function

Early research from the 1990s indicated that GHRH analogs, including CJC-1295 DAC, may play a role in ovulation cycles. In certain animal models, increases in growth hormone and IGF-1 were observed during ovulation, and exposure to analogs such as CJC-1295 DAC was suggested to potentially support ovulation and sperm production. Findings remain inconclusive and require further study.

Conclusion

CJC-1295 DAC is a synthetic GHRH analog featuring modifications designed to enhance stability and prolong its presence in biological systems. Research suggests potential roles in supporting growth hormone release, receptor signaling, growth regulation, and reproductive processes. While promising in various experimental contexts, much remains under investigation, and findings continue to evolve.

References

1. Newton, A. C., Bootman, M. D., & Scott, J. D. (2016). Second Messengers. Cold Spring Harbor perspectives in biology, 8(8), a005926. https://doi.org/10.1101/cshperspect.a005926
2. Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog. Endocrinology. 2005 Jul;146(7):3052-8. doi: 10.1210/en.2004-1286. Epub 2005 Apr 7. PMID: 15817669.
3. Ionescu M, Frohman LA. Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. J Clin Endocrinol Metab. 2006 Dec;91(12):4792-7. doi: 10.1210/jc.2006-1702. Epub 2006 Oct 3. PMID: 17018654.
4. Guo S, Li Z, Yan L, Sun Y, Feng Y. GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity. Drug Des Devel Ther. 2018 Jun 7;12:1621-1631. doi: 10.2147/DDDT.S162541. PMID: 29922037; PMCID: PMC5995291.
5. Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.
6. Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
7. Martin, B., Lopez de Maturana, R., Brenneman, R., Walent, T., Mattson, M. P., & Maudsley, S. (2005). Class II G protein-coupled receptors and their ligands in neuronal function and protection. Neuromolecular medicine, 7(1-2), 3–36. https://doi.org/10.1385/nmm:7:1-2:003
8. Gautam D, Jeon J, Starost MF, Han SJ, Hamdan FF, Cui Y, Parlow AF, Gavrilova O, Szalayova I, Mezey E, Wess J. Neuronal M3 muscarinic acetylcholine receptors are essential for somatotroph proliferation and normal somatic growth. Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6398-403. doi: 10.1073/pnas.0900977106. Epub 2009 Mar 30. PMID: 19332789; PMCID: PMC2662962.

Disclaimer:
The products mentioned are intended solely for laboratory research and in-vitro experimentation. They are not approved for human or animal use of any kind. All details provided are for educational purposes only. By purchasing from this site, you agree to comply with our Terms and Conditions.